Title:
可溶性内皮細胞プロテインC/活性化プロテインCレセプターを使用する診断アッセイ
Document Type and Number:
Japanese Patent JP4308900
Kind Code:
B2
Abstract:
Plasma EPCR has been isolated, characterized and shown to block cellular protein C activation and APC anticoagulant activity. Plasma EPCR appears to be about 43,000 daltons and circulates at approximately 100 ng/ml (98.4+/-27.8 ng/ml, n=22). Plasma EPCR bound activated protein C with an affinity similar to that of recombinant soluble EPCR (Kdapp approximately 30 nM), and inhibits both protein C activation on an endothelial cell line and APC anticoagulant activity in a one-stage factor Xa clotting assay. Soluble plasma EPCR appears to attenuate the membrane-bound EPCR augmentation of protein C activation and the anticoagulant function of activated protein C. Soluble EPCR has also been detected in urine. Levels of soluble EPCR can rise in inflammatory disease associated with vascular injury and appear to be correlated with inflammation and disease states associated with abnormal coagulation. Since EPCR expression is restricted to larger vessels and is usually negative in cappillaries, these observations provide a mechanism for analyzing injury/stimulation of large vessel endothelial cells.
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Inventors:
Charles Tea. Esmon
Devoller Jay. Stearns-Kurosawa
Shinichiro Kurosawa
Devoller Jay. Stearns-Kurosawa
Shinichiro Kurosawa
Application Number:
JP2001365405A
Publication Date:
August 05, 2009
Filing Date:
November 29, 2001
Export Citation:
Assignee:
OKLAHOMA MEDICAL RESEARCH FOUNDATION
International Classes:
C07K14/705; C07K14/74; C07K16/28; C07K16/38; C12N15/00; C12P21/08; G01N33/53; G01N33/564; G01N33/566; G01N33/68; G01N33/86
Foreign References:
| WO1996005303A1 |
Other References:
J. Biol. Chem.,1996年,Vol.271, No.29,pp.17491-17498
J. Biol. Chem.,1996年,Vol.271, No.29,pp.17499-17503
J. Biol. Chem.,1996年,Vol.271, No.29,pp.17499-17503
Attorney, Agent or Firm:
Hidesaku Yamamoto