Title:
DISUBSTITUTED ACETYLENE HAVING RETINOID LIKE ACTIVITY
Document Type and Number:
Japanese Patent JPS63255277
Kind Code:
A
Abstract:
Retinoid-like activity is exhibited by compounds of the formula where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH or a pharmaceutically acceptable salt, ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or -COR1 or a ketal derivative where R1 is -(CH2)mCH3 where m is 0-4, or a pharmaceutically acceptable salt thereof.
Inventors:
ROSHIYANTA EI ESU CHIYANDORARA
Application Number:
JP7085588A
Publication Date:
October 21, 1988
Filing Date:
March 22, 1988
Export Citation:
Assignee:
ALLERGAN INC
International Classes:
A61K31/38; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/445; A61K31/47; A61K31/495; A61K31/50; A61K31/505; A61P3/02; A61P17/00; A61K31/35; A61P35/00; A61P37/00; A61P43/00; C07D215/12; C07D311/58; C07D335/06; C07D401/04; C07D401/06; C07D405/04; C07D405/06; C07D407/04; C07D407/06; C07D409/04; C07D409/06; (IPC1-7): A61K31/35; A61K31/38; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/50; A61K31/505; C07D401/06; C07D405/06; C07D407/06; C07D409/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)