To provide a new medicine for treating migraine.
Isolated nucleic acid molecules encoding human 5-HT1D receptors, isolated proteins which are human 5-HT1D receptors, vectors comprising isolated nucleic acid molecules encoding human 5-HT1D receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT1D receptors, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT1D receptors, antisense oligonucleotides complementary to any sequence of a nucleic acid molecule which encodes a human 5-HT1D receptor, pharmaceutical compounds related to human 5-HT1D receptors, and nonhuman transgenic animals which express DNA, a normal or a mutant human 5-HT1D receptor are provided. Further, methods for determining ligand binding, detecting expression, medicine screening, and treatment involving the human 5-HT1D receptor are provided.
BRANCHEK THERESA
HARTIG PAUL R
