DRUG DELIVERY CARRIER, CONJUGATES AND COMPOSITION COMPRISING THE SAME AS WELL AS METHOD OF ADMINISTERING THE SAME

Title:

DRUG DELIVERY CARRIER, CONJUGATES AND COMPOSITION COMPRISING THE SAME AS WELL AS METHOD OF ADMINISTERING THE SAME

Document Type and Number:

Japanese Patent JP2019194220

Kind Code:

A

Abstract:

To provide novel drug delivery carriers and conjugates which can easily penetrate blood-brain barrier, blood-nerval barrier, blood-retinal barrier, blood-cerebrospinal fluid barrier and the like where only particular drugs can penetrate because of high drug permselectivity, and to provide compositions containing the same, as well as to provide methods of administering the same.SOLUTION: Provided is a composition for administering to a subject according to a dosage regimen which comprises a drug delivery carrier, the dosage regimen comprising (1) fasting the subject or inducing hypoglycaemia; (2) administering the composition to the subject; and (3) inducing the increase of blood glucose levels in the subject, the carrier having an outer surface which is modified by GLUT1 ligand. The carrier is a vesicle including the agent, and preferably 10 to 40 mol% of the polymer which forms the vesicle is modified by GLUT1 ligand.SELECTED DRAWING: Figure 1

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Inventors:

KATAOKA KAZUNORI
ANRAKU YASUTAKA
NISHIYAMA NOBUHIRO
MIYATA KANJIRO
ISHII TAKEHIKO
MATSUMOTO TAMOTSU
FUKUZATO YU
MIZOGUCHI AKISUKE
YOKOTA TAKANORI
KUWABARA HIROYA
NISHINA KAZUTAKA
MIZUSAWA HIDEHIRO

Application Number:

JP2019116818A

Publication Date:

November 07, 2019

Filing Date:

June 25, 2019

Export Citation:

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Assignee:

UNIV TOKYO
UNIV TOKYO MEDICAL & DENTAL

International Classes:

A61K47/54; A61K9/107; A61K31/575; A61K31/7088; A61K31/713; A61K39/395; A61K45/00; A61K47/26; A61K47/34; A61K47/42; A61K47/69; A61K48/00; A61K49/00; A61K49/04; A61P25/00; B82Y5/00; C07H3/02; C07J9/00

Attorney, Agent or Firm:

Seiji Ohno
Yuko Matsuniya
Umeda Shinsuke
Hiroshi Morita

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