Title:
効率的な肝炎ウイルスの抗体誘導方法、抗体および検出系
Document Type and Number:
Japanese Patent JP7412689
Kind Code:
B2
Abstract:
[Problem]To provide an examination system that can recognize a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity.[Solutions]It was elucidated that Dane particles are associated with specific glycan structures, and this enabled the construction of a new detection system for infectious, i.e., nucleic acid-containing, hepatitis B virus particles and the provision of a neutralizing antibody that recognizes a glycosylated antigen and that exhibits an infection-inhibiting activity.
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Inventors:
Hisashi Narimatsu
Kiyohiko Agata
Hiroyuki Kaji
Atsushi Kuno
Takashi Sato
Yasunori Chiba
Akira Tsugayauchi
Hiroki Shimizu
Maki Sogabe
Takanori Agatsuma
Masashi Mizokami
Masashi Korenaga
Kazuto Tajiri
Tatsuhiko Ozawa
Kiyohiko Agata
Hiroyuki Kaji
Atsushi Kuno
Takashi Sato
Yasunori Chiba
Akira Tsugayauchi
Hiroki Shimizu
Maki Sogabe
Takanori Agatsuma
Masashi Mizokami
Masashi Korenaga
Kazuto Tajiri
Tatsuhiko Ozawa
Application Number:
JP2020523182A
Publication Date:
January 15, 2024
Filing Date:
June 06, 2019
Export Citation:
Assignee:
National Institute of Advanced Industrial Science and Technology
National University Corporation Toyama University
National University Corporation Toyama University
International Classes:
C12N15/13; A61K39/29; A61P31/20; C07K14/02; C07K16/08; C12N15/63; G01N33/576
Other References:
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Analytical Chemistry,2018年08月03日,Vol.90,p.10196-10203
西口修平,Hbs抗原の測定法と臨床的意義,肝臓,2014年,第55巻, 第6号,p.310-324
Journal of General Virology,2000年,Vol.81,p.369-378
Journal of Virology,2003年09月,Vol.77, No.17,p.9511-9521
Tohoku J. Exp. Med.,2015年06月09日,Vol.236, No.2,p.131-138
Hepatitis Monthly,2013年09月07日,Vol.13, No.9,e12280 (p.1-9)
Molecular Immunology,1982年,Vol.19, No.9,p.1087-1093
Journal of General Virology,2004年,Vol.85,p.2045-2053,DOI 10.1099/vir.0.79932-0
Journal of Medical Virology,1989年,Vol.28,p.7-12
Analytical Chemistry,2018年08月03日,Vol.90,p.10196-10203
西口修平,Hbs抗原の測定法と臨床的意義,肝臓,2014年,第55巻, 第6号,p.310-324
Journal of General Virology,2000年,Vol.81,p.369-378
Journal of Virology,2003年09月,Vol.77, No.17,p.9511-9521
Tohoku J. Exp. Med.,2015年06月09日,Vol.236, No.2,p.131-138
Hepatitis Monthly,2013年09月07日,Vol.13, No.9,e12280 (p.1-9)
Molecular Immunology,1982年,Vol.19, No.9,p.1087-1093
Attorney, Agent or Firm:
Sonoda & Kobayashi Patent Attorneys Corporation