Title:
ENTERIC PARTICLE
Document Type and Number:
Japanese Patent JP3187502
Kind Code:
B2
Abstract:
PURPOSE: To provide the subject enteric particle insoluble in the stomach after oral administration, not dissolved till it reaches the intestine, capable of allowing a large amount of a bioactive substance such as Lactobacillus viable cell to be dissolved in the intestine with out suffering the effect of the low pH gastric juice and stable even after long-term storage.
CONSTITUTION: A bioactive substance such as Lactobacillus or Lactobacillus bifidus, exhibiting a high utilization in the living body (especially the intestine) and readily affected by the gastric juice is used for granulation. The above- mentioned substance is coated with two layers of (A) a layer containing fats and oils (preferably 30 to 45°C melting point), a vehicle and a hydrous alcohol soluble protein (preferably zein) and (B) a layer containing a hydrous alcohol soluble protein to obtain the objective enteric particle having the above- mentioned effects. In addition, it doesn't matter which is applied first, the (A) layer or the (B) layer. When the (A) layer is applied first, a particle excellent in acid resistance is produced with an excellent work efficiency. When the (B) layer is applied first, a particle having a small particle size can be obtained. The (A) and (B) layers may be alternately applied many times to obtain a multilayer particle.
Inventors:
Shigeru Hizaki
Masaaki Yamauchi
Masaaki Yamauchi
Application Number:
JP2186292A
Publication Date:
July 11, 2001
Filing Date:
January 09, 1992
Export Citation:
Assignee:
Kanebo Co., Ltd.
International Classes:
A23L1/00; A23L1/28; A23L1/30; A23L5/00; A23L31/00; A23L33/10; A23L33/12; A23L33/135; A61K9/14; A61K9/20; A61K9/38; A61K35/74; A61K35/742; A61K35/744; A61K35/745; A61K35/747; C12N1/04; C12N1/20; (IPC1-7): A61K9/38; A23L1/00; A61K9/14; A61K35/74; C12N1/04
Domestic Patent References:
| JP62120316A | ||||
| JP3920712B1 | ||||
| JP3711842B1 |