EphB3-SPECIFIC ANTIBODY AND USE THEREOF

Title:

EphB3-SPECIFIC ANTIBODY AND USE THEREOF

Document Type and Number:

Japanese Patent JP2013153769

Kind Code:

A

Abstract:

To provide EphB3-specific antibodies, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods for preventing and treating cancer.

An antibody binds the extracellular domain of EphB3 with an affinity (KD) of 10^-6 M or less and competes with any of antibodies XPA.04.001, XPA.04.013, XPA.04.018, XPA.04.048, XHA.05.337, XHA.05.200, XHA.05.111, XHA.05.005, XHA.05.228, XHA.05.030, XHA.05.964, or XHA.05.885 for binding to EphB3 by more than 75% is provided.

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Inventors:

HSU JEFF
MASAT LINDA
ABRAHAM JUDY
HANDA MASAHISA
SCHEYER SIEW

Application Number:

JP2013107204A

Publication Date:

August 15, 2013

Filing Date:

May 21, 2013

Export Citation:

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Assignee:

NOVARTIS AG
XOMA TECHNOLOGY LTD

International Classes:

C12N15/09; A61K39/395; A61K45/00; A61P35/00; A61P43/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; G01N33/15; G01N33/50; G01N33/574

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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