Title:
エピトープアナログ
Document Type and Number:
Japanese Patent JP5166025
Kind Code:
B2
Abstract:
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.
Inventors:
Riu, Lipin
Bot, adrian
Diamond, David Sea.
Rhino, didon
Bot, adrian
Diamond, David Sea.
Rhino, didon
Application Number:
JP2007516810A
Publication Date:
March 21, 2013
Filing Date:
June 17, 2005
Export Citation:
Assignee:
Mankind Corporation
International Classes:
C12N15/09; A61K39/00; A61K39/39; A61P35/00; A61P35/02; A61P37/04; C07K7/06; G01N33/53
Domestic Patent References:
| JP2004513873A | ||||
| JP2003530554A | ||||
| JP2003502079A |
Foreign References:
| WO2004011483A1 | ||||
| US6777388 | ||||
| WO2004030616A1 | ||||
| WO2003064457A1 | ||||
| WO2002081646A1 |
Other References:
Proc. Natl. Acad. Sci. USA,1993年,Vol.90,p.1227-1231
Peptide Science,THE JAPANESE PEPTIDE SOCIETY,2002年 3月,Vol.2001,p.175-178
Peptide Science,THE JAPANESE PEPTIDE SOCIETY,2002年 3月,Vol.2001,p.175-178
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Mayuko Wakuda
Tsutomu Toyama
Hidemi Matsukura
Mayuko Wakuda
Tsutomu Toyama