Title:
エポチロンの合成とその中間体及びその類似物並びにその使用
Document Type and Number:
Japanese Patent JP4579351
Kind Code:
B2
Abstract:
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
Inventors:
Danish Chevski, Samuel, Jay
Baylog, Aaron
Peter,vertate
Su, Daishi
Butterfly, tin-chow
Men, don, fan
Kameneka, Ted
Sorensen, Eric, Jay
Baylog, Aaron
Peter,vertate
Su, Daishi
Butterfly, tin-chow
Men, don, fan
Kameneka, Ted
Sorensen, Eric, Jay
Application Number:
JP50109599A
Publication Date:
November 10, 2010
Filing Date:
December 03, 1997
Export Citation:
Assignee:
Sloan-Kettering Institute For Cancer Research
International Classes:
C07D277/06; A61K31/335; C07D417/06; A61K31/337; A61K31/422; A61K31/425; A61K31/426; A61K31/427; A61K31/429; A61K31/475; A61K31/70; A61K35/00; A61K45/06; A61P35/00; A61P35/02; C07C33/02; C07C43/12; C07C47/277; C07C69/007; C07C69/716; C07C69/738; C07C323/14; C07D263/32; C07D277/22; C07D277/24; C07D277/30; C07D313/00; C07D413/06; C07D417/14; C07D493/04; C07F5/02; C07F7/18
Other References:
Cancer Research, 1995, 55, 11, p.2325-2333
The Journal of Organic Chemistry, 15 Nov 1996, 61, 23, p.8000-8001
Angew.Chem.Int.Ed.Engl., 14 Mar 1997, 36, 5, p.525-527
The Journal of Organic Chemistry, 15 Nov 1996, 61, 23, p.8000-8001
Angew.Chem.Int.Ed.Engl., 14 Mar 1997, 36, 5, p.525-527
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro