EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION

Japanese Patent JP2010131014

A

To provide a novel and a large number of molecular genetic methods and compositions for evolution of whole and partial genomes.

The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties (including enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites). For example, methods includes the steps of fertilizing pooled male-female gametes derived from different species, growing it up to be a reproducibly survival organism, preparing an organism library of various multicellular organisms by repeating the mating process, and selecting an organism having a desired trait or property.

COPYRIGHT: (C)2010,JPO&INPIT

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DEL CARDAYRE STEPHEN
TOBIN MATTHEW
STEMMER WILLEM P C
NESS JON E
MINSHULL JEREMY
PATTEN PHILIP A
SUBRAMANIAN VENKITESWATAN
CASTLE LINDA A
KREBBER CLAUS M
BASS STEVE
ZHANG YING-XIN
COX TONY
HUISMAN GJALT
YUAN LING
AFFHOLTER JOSEPH A

JP2009288163A

June 17, 2010

December 18, 2009

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MAXYGEN INC

A01H1/00; A01H5/00; A01K67/02; A01K67/027; C07K14/245; C12N1/19; C12N5/10; C12N15/09; C12N15/10; C12N15/82; C12P17/16; C12Q1/68

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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