Title:
未発症の『危険相』から関節リウマチ、ＡＡＶ、又はシェーグレン症候群への遷移のバイオマーカーとしてのＦａｂ結合型糖鎖
Document Type and Number:
Japanese Patent JP7493145
Kind Code:
B2
Abstract:
Means and methods for determining whether an individual that does not have rheumatoid arthritis, AAV or Sjögren syndrome at the moment of sampling is at risk of developing the disease, the method comprising determining whether an antibody-containing sample of the individual comprises an autoantibody associated with the disease that comprises an N-linked glycosylation at one or more positions in a Fab-portion of the antibody, the method further comprising determining the risk of the individual for developing the disease. The disease is preferably rheumatoid arthritis.
Inventors:
Hauzingha, Thomas Willem Johannes
Reinaldus Everardus Maria, Tooth
Trow, Leendert Adrianus
Scherrer, Hans Ulrich
Reinaldus Everardus Maria, Tooth
Trow, Leendert Adrianus
Scherrer, Hans Ulrich
Application Number:
JP2022142927A
Publication Date:
May 31, 2024
Filing Date:
September 08, 2022
Export Citation:
Assignee:
Academi Siekenhaus Leiden Ha. O. Day. En. Lumuk
International Classes:
G01N33/53
Foreign References:
| WO2015194350A1 | ||||
| US20110311999 |
Other References:
Yoann Rombouts,Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis,Annals of the rheumatic diseases,2015年01月13日,Vol.75 No.3,Page.578-585
Jing Wu,Analysis of Glycan Variation on Glycoproteins from Serum by the Reverse Lectin-Based ELISA Assay,J. Proteome Res.,2014年,Vol.13,Page.2197-2204
Fabian Kasermann,Analysis and Functional Consequences of Increased Fab-Sialylation of Intravenous Immunoglobulin (IVIG) after Lectin Fractionation,PLoS ONE,2012年06月04日,Vol.7 No.6,Page.e37243
Jing Wu,Analysis of Glycan Variation on Glycoproteins from Serum by the Reverse Lectin-Based ELISA Assay,J. Proteome Res.,2014年,Vol.13,Page.2197-2204
Fabian Kasermann,Analysis and Functional Consequences of Increased Fab-Sialylation of Intravenous Immunoglobulin (IVIG) after Lectin Fractionation,PLoS ONE,2012年06月04日,Vol.7 No.6,Page.e37243
Attorney, Agent or Firm:
Mitsuru Kimura
Yasushi Morikawa
Kei Sakurada
Hideki Mie
Yasushi Morikawa
Kei Sakurada
Hideki Mie
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