Title:
高速メチル化法、PETトレーサー調製用キット、及びPET用トレーサーの製造方法
Document Type and Number:
Japanese Patent JP5279077
Kind Code:
B2
Abstract:
It is intended to provide a method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a mild condition rapidly in high yield using an organic boron compound whose toxicity is not so high as a substrate; a kit for preparing a PET tracer to be used in the same, and a method of producing a PET tracer using the same. In an aprotic polar solvent, methyl iodide or X-CH2F (wherein X is a functional group which can be easily released as an anion), an organic boron compound in which an aromatic ring or an alkenyl group is attached to boron are subjected to cross-coupling in the presence of a palladium(0) complex, a phosphine ligand, and a base.
Inventors:
Suzuki Masaaki
Koji Doi
Hideo Tsukada
Koji Doi
Hideo Tsukada
Application Number:
JP2008530959A
Publication Date:
September 04, 2013
Filing Date:
August 24, 2007
Export Citation:
Assignee:
RIKEN
Hamamatsu Photonics Co., Ltd.
Hamamatsu Photonics Co., Ltd.
International Classes:
C07C1/32; A61K51/00; C07C11/02; C07C13/20; C07C15/06; C07C15/44; C07C17/263; C07C22/08; C07C25/13; C07C29/32; C07C33/03; C07C41/30; C07C43/205; C07C67/293; C07C67/343; C07C69/533; C07C69/76; C07C69/78; C07C201/12; C07C205/06; G01T1/161; C07B59/00; C07B61/00
Attorney, Agent or Firm:
Tomimasa Konishi
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