Title:
FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO PCSK9
Document Type and Number:
Japanese Patent JP2016104792
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide fibronectin based scaffold domain proteins that bind to proprotein convertase subtilisin kexin type 9 (PCSK9).SOLUTION: The invention provides polypeptides comprising fibronectin III 10th domain (10Fn3), which has at least one loop selected from loops BC, DE and FG with an altered amino acid sequence relative to the sequence of the corresponding loop of the human 10Fn3 domain, the polypeptides binding to PCSK9.EFFECT: The polypeptides can be used in the therapeutic applications for treating atherosclerosis, hypercholesterolemia, and other cholesterol related diseases.SELECTED DRAWING: Figure 6
Inventors:
RAY CAMPHAUSEN
SHARON T CLOAD
DAVIS JONATHAN H
FABIENNE M DENHEZ
AMNA SAEED-KOTHE
DASA LIPOVSEK
LOW CHEE MENG
TRACY S MITCHELL
GINGER C RAKESTRAW
KATIE A RUSSO
CHING-HSIUNG FREDERICK LO
BOWMAN MIAO
PARKER REX A
DOREE F SITKOFF
SHARON T CLOAD
DAVIS JONATHAN H
FABIENNE M DENHEZ
AMNA SAEED-KOTHE
DASA LIPOVSEK
LOW CHEE MENG
TRACY S MITCHELL
GINGER C RAKESTRAW
KATIE A RUSSO
CHING-HSIUNG FREDERICK LO
BOWMAN MIAO
PARKER REX A
DOREE F SITKOFF
Application Number:
JP2016008940A
Publication Date:
June 09, 2016
Filing Date:
January 20, 2016
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
C07K14/78; A61K38/36; A61K47/34; A61K47/36; A61K47/42; A61K47/48; A61P3/06; A61P9/10
Domestic Patent References:
| JP2001500531A | 2001-01-16 |
Foreign References:
| WO2008125623A2 | 2008-10-23 | |||
| WO2009133208A1 | 2009-11-05 | |||
| WO2009102421A2 | 2009-08-20 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura
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