To provide a new optically active quaternary ammonium salt having high performances as an axial asymmetry-containing spiro type phase transfer catalyst for an asymmetric alkylation reaction of a glycine derivative, advantageous to the number of catalyst synthetic steps and having the same structure of each ring of the spiro skeleton and to provide a method for producing the same and a method for recovering and purification.
An axial asymmetry-containing spiro type ammonium salt in which a substituent including a perfluoroalkyl group is introduced is excellent as the phase transfer catalyst. The ammonium salt is used for the asymmetric alkylation reaction of the glycine derivative and can then be recovered and purified without deteriorating catalyst performances with a fluorous solvent.
COPYRIGHT: (C)2005,JPO&NCIPI
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