NEW MATERIAL:Foliaspongin shown by the formula. Melting point: 186W189°C. Specific rotatory power:[α]D15+44° (chloroform, C=0.17). Ultraviolet absorption spectrum: not exhibiting absorption in a wave length longer than 210nm. Solubility: soluble in chloroform, acetone, pyridine, slightly soluble in methanol, ethanol, insoluble in water.
USE: A pharmaceutically active substance having a controlling action on the propagation of granulation tissue.
PROCESS: Phyllospongia foliasence is extracted with an organic solvent or a mixed solvent of water and the organic solvent to give an extracted solution, which is concentrated, foliaspongin an active ingredeint is isolated by utilizing the difference of partitions between two kinds of solutions, the difference of adsorption affinity against adsorbents, the difference of solubility against solvent, the difference of precipitation ration, etc., it is purified and crystallized by using a proper solvent.
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TSUKITANI YASUMASA
SHIMIZU IWAO
