Title:
真菌の細胞壁合成遺伝子
Document Type and Number:
Japanese Patent JP4097194
Kind Code:
B2
Abstract:
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
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Inventors:
Katsuhei Tsukahara
Katsura
Aiji Koji
Kazutaka Nakamoto
Mamiko Tsuchiya
Naoaki Watanabe
Oba Shiki
Takashi Tsukada
Ueda Norihiro
Keigo Tanaka
Junko Kai
Katsura
Aiji Koji
Kazutaka Nakamoto
Mamiko Tsuchiya
Naoaki Watanabe
Oba Shiki
Takashi Tsukada
Ueda Norihiro
Keigo Tanaka
Junko Kai
Application Number:
JP2002509480A
Publication Date:
June 11, 2008
Filing Date:
July 06, 2001
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C12N15/09; A61K31/00; A61K31/4355; A61K31/4365; A61K31/437; A61K31/44; A61K31/472; A61K31/4725; A61K31/5377; A61P31/10; C07D213/68; C07D217/18; C07D217/20; C07D491/048; C07D491/056; C07K14/37; C07K14/38; C07K14/39; C07K14/395; C07K14/40; C07K16/14; C12N1/15; C12N1/19; C12P21/02; C12P21/08; C12Q1/02; G01N33/15; G01N33/50; A61K31/427; A61K38/00; A61K39/395; A61K45/00; A61P43/00; C07D213/16; C07D213/61; C07D213/65; C07D213/69; C07D213/74; C07D217/02; C07D401/10; C07D405/06; C07D405/12; C07D471/04; C07D495/04
Foreign References:
| WO2000001387A1 |
Other References:
McDougall, R. C. et al. 'S. pombe chromosome I cosmid c144', EMBL [online], 27 Oct. 1999, [retrieved on 23 August 2006] EMBL accession no. AL132675
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi