Title:
Fusion pyrimidine as inhibitor of p97 complex
Document Type and Number:
Japanese Patent JP6109937
Kind Code:
B2
Abstract:
Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.
Inventors:
Chow Han-Chi
Parrati Francesco
Wustrow debit
Parrati Francesco
Wustrow debit
Application Number:
JP2015523293A
Publication Date:
April 05, 2017
Filing Date:
July 19, 2013
Export Citation:
Assignee:
Cleve Biosciences, Inc.
International Classes:
C07D403/04; A61K31/517; A61K31/519; A61K31/5377; A61P3/00; A61P3/06; A61P3/10; A61P25/00; A61P25/16; A61P25/28; A61P31/00; A61P35/00; A61P37/06; C07D471/04; C07D491/048; C07D491/052
Domestic Patent References:
| JP2006525357A |
Foreign References:
| WO2011140527A2 | ||||
| WO2011018417A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto