Title:
ＧＡＲＰ－ＴＧＦ－β抗体
Document Type and Number:
Japanese Patent JP7118135
Kind Code:
B2
Abstract:
The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.
Inventors:
Van der bonning, sebastian
Bolciones, Philip
Dreiell, Torsten
Marien, Lore
Do Book, Hitte
Lienard, Stephanie
Lucas, Sophie
Cooley, Pierre
Bolciones, Philip
Dreiell, Torsten
Marien, Lore
Do Book, Hitte
Lienard, Stephanie
Lucas, Sophie
Cooley, Pierre
Application Number:
JP2020512919A
Publication Date:
August 15, 2022
Filing Date:
May 11, 2018
Export Citation:
Assignee:
argenks b.f.e
Universite Catholic de Louvain
Universite Catholic de Louvain
International Classes:
C12N15/13; A61K39/00; A61K39/395; A61K45/00; A61P9/00; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/04; A61P43/00; C07K16/22; C07K16/28; C07K16/46; C12M1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08
Domestic Patent References:
| JP2016529892A |
Foreign References:
| WO2017051888A1 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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