Title:
GENE ASSOCIATED WITH ARTERIOSCLEROTIC DISEASE, AND USE THEREOF
Document Type and Number:
Japanese Patent JP2011125296
Kind Code:
A
Abstract:
To provide a gene associated with arteriosclerotic diseases and its use to utilize characteristic features of the gene.
There are provided a method for examining the presence or absence of an arteriosclerotic disease risk factor by using polymorphism mutation found on two kinds of genes identified to be associated with arteriosclerotic diseases such as cerebral infarction as an index based on a large-scale case-control correlation investigation using atherothrombotic cerebral infarction as a target; a method for screening a therapeutic agent for arteriosclerotic diseases by using expression or function of the gene as an index; and a therapeutic and preventing agent for arteriosclerotic diseases to suppress the expression of the gene.
Inventors:
IIDA MITSUO
KIYOHARA YUTAKA
KITAZONO TAKANARI
MATSUSHITA TOMONAGA
KUBO MITSUAKI
NAKAMURA YUSUKE
OMAE TERUO
ENDO TADASHI
KIYOHARA YUTAKA
KITAZONO TAKANARI
MATSUSHITA TOMONAGA
KUBO MITSUAKI
NAKAMURA YUSUKE
OMAE TERUO
ENDO TADASHI
Application Number:
JP2009288726A
Publication Date:
June 30, 2011
Filing Date:
December 21, 2009
Export Citation:
Assignee:
HISAYAMA RES INST FOR LIFESTYLE DISEASES
UNIV TOKYO
RIKAGAKU KENKYUSHO
MITSUBISHI TANABE PHARMA CORP
UNIV TOKYO
RIKAGAKU KENKYUSHO
MITSUBISHI TANABE PHARMA CORP
International Classes:
C12Q1/68; A61K31/7088; A61K31/7105; A61K39/395; A61K45/00; A61K45/06; A61K48/00; A61P9/10; C12N15/09; C12N15/113; C12Q1/02; G01N33/15; G01N33/50; C07K16/18
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto