Title:
遺伝子破壊、それに関連する組成物および方法
Document Type and Number:
Japanese Patent JP2009527227
Kind Code:
A
Abstract:
The present invention relates to transgenic animals, as wells as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PR021184, PRO7434, PRO9822, PRO8933, PRO9836, PRO9854, PRO9863, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration, or correction of diseases or dysfunctions associated with gene disruptions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorder; or developmental abnormalities.
Inventors:
Bollinger, Christie Ray
Horner, Allison Ann Buyers
Combs, Catherine Yi.
Calvertson, Lin Lin
Cunningham, Jamie-Joe
Deso Beige, Frederick
Edwards, Joel
Gilgis, Rosemary
Green,leslie
McLain, Dina Rebecca
Mines, Raleigh Janet
Montgomery, Charles A.
Payne, Bobby Joe
Philips, Heidi
See, Chen-Chen
Sparks, Mary Jean
Stara, joian
Tan, Tracy Two-Lin
Townsend, Teresa Gail
Vogel, Peter
Sevo, Tracy Ellen Willis
Horner, Allison Ann Buyers
Combs, Catherine Yi.
Calvertson, Lin Lin
Cunningham, Jamie-Joe
Deso Beige, Frederick
Edwards, Joel
Gilgis, Rosemary
Green,leslie
McLain, Dina Rebecca
Mines, Raleigh Janet
Montgomery, Charles A.
Payne, Bobby Joe
Philips, Heidi
See, Chen-Chen
Sparks, Mary Jean
Stara, joian
Tan, Tracy Two-Lin
Townsend, Teresa Gail
Vogel, Peter
Sevo, Tracy Ellen Willis
Application Number:
JP2008555441A
Publication Date:
July 30, 2009
Filing Date:
February 09, 2007
Export Citation:
Assignee:
GENENTECH,INC.
International Classes:
C12N5/10; A61K38/00; A61K45/00; A61P1/04; A61P3/02; A61P3/06; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P27/02; A61P27/12; A61P35/00; A61P37/00; A61P37/06; A61P37/08; C12N15/09; C12Q1/02; A01K67/027
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita