Title:
GENE AND POLYPEPTIDE ASSOCIATED WITH ULTRAVIOLET RADIATION-MEDIATED SKIN DAMAGE AND USES THEREOF
Document Type and Number:
Japanese Patent JP2004290197
Kind Code:
A
Abstract:
To provide polynucleotides and their encoded gene products that are expressed in skin cells, particularly keratinocytes, and methods of using the same.
The invention provides polynucleotides encoding several new protein kinases that are c-Jun N-terminal kinase kinase kinases, i.e., MLK4, PAK4, PAK5 and YSK2. In addition, the invention provides methods of using the disclosed polynucleotides and their gene products in drug discovery, particularly in screening for drugs that can reduce ultraviolet light-induced damage of the skin, inflammation and psoriasis, and drugs that can enhance wound healing.
Inventors:
BLUMENBERG MIROSLAV
GAZEL ALIX M
GAZEL ALIX M
Application Number:
JP2004139636A
Publication Date:
October 21, 2004
Filing Date:
May 10, 2004
Export Citation:
Assignee:
UNIV NEW YORK
International Classes:
G01N33/50; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12N15/54; C12Q1/02; C12Q1/48; C12Q1/68; G01N33/15; (IPC1-7): C12N15/09; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12Q1/02; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kiyoshi Murakami
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kiyoshi Murakami
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