Title:
成長ホルモン放出ペプチド
Document Type and Number:
Japanese Patent JP5025668
Kind Code:
B2
Abstract:
Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2 (I) or a pharmaceutically acceptable salt thereof, wherein: A1 is Aib, Apc or Inp; A2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Na1, D-Ser(Bzl), or D-Trp; A3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A4 is 2Fua, Orn, 2Pa1, 3Pal, 4Pa1, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A5 is Apc, Dab, Dap, Lys, Orn, or deleted; R1 is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl; and R2 is OH or NH2; and pharmaceutical compositions and methods of use thereof.
Inventors:
Don, Zen Jin
Application Number:
JP2009014262A
Publication Date:
September 12, 2012
Filing Date:
January 26, 2009
Export Citation:
Assignee:
IPSEN PHARMA S.A.S.
International Classes:
C07K7/06; C12Q1/02; A61K38/00; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/04; A61P9/12; A61P15/08; A61P19/02; A61P19/10; A61P21/00; A61P27/02; A61P35/00; A61P43/00; C07K5/02; C07K5/04; C07K5/06; C07K5/08; C07K5/10; C07K5/107; C07K5/117; C07K7/02; C07K7/04; C07K14/60
Domestic Patent References:
| JP10509152A | ||||
| JP11507928A | ||||
| JP9507217A | ||||
| JP10506114A | ||||
| JP4365319B2 |
Other References:
J. Biol. Chem.,2001年11月 2日,Vol.276, No.44,p.40441-40448
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri