Title:
ＨａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａｅＩＶ型ピリ線毛
Document Type and Number:
Japanese Patent JP5616766
Kind Code:
B2
Abstract:
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H . influenzae and methods of treating and preventing H. influenzae related pathological conditions.
Inventors:
ローレン オー． ベイカレッツ
ロバート エス． マンソン ジュニア
ロバート エス． マンソン ジュニア
Application Number:
JP2010267903A
Publication Date:
October 29, 2014
Filing Date:
November 30, 2010
Export Citation:
Assignee:
ネイションワイド チルドレンズ ホスピタル， インコーポレイテッド
International Classes:
C12N15/09; A61K31/711; A61K39/02; A61K39/102; A61P11/00; A61P15/00; A61P27/16; A61P31/04; C07H21/04; C07K14/195; C07K14/285; C07K19/00; C12N15/74; A61K39/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita