Title:
HEPATITIS C VIRUS INHIBITORS
Document Type and Number:
Japanese Patent JP2015172064
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for oral administration for the treatment of hepatitis C virus (HCV) infection.SOLUTION: The present invention relates to a pharmaceutical composition for oral administration for the treatment of HCV infection that comprises a compound represented by the following structure or a pharmaceutically acceptable salt thereof, in which the HCV is HCV1b genotype. The salt is preferably dihydrochloride. One or two additional compounds having anti-HCV activity are preferably administrated before, after, or at the same time with administration of the composition. The additional composition is preferably selected from among interferon, ribavirin. interleukin 2, interleukin 6, interleukin 12, a compound that enhances the development of a type 1 helper T cell response, interfering RNA, anti-sense RNA, imiqimod, an inosine 5'-monophospate dehydrogenase inhibitor, amantadine, and rimantadine.
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Inventors:
BACHAND CAROL
BELEMA MAKONEN
DEON DANIEL H
GOOD ANDREW C
GOODRICH JASON
JAMES CLINT A
LAVOIE RICO
LOPEZ OMAR D
MARTEL ALAIN
MEANWELL NICHOLAS A
NGUYEN VAN N
ROMINE JEFFREY LEE
RUEDIGER EDWARD H
SNYDER LAWRENCE B
ST LAURENT DENIS R
YANG FUKANG
LANGLEY DAVID R
WANG GAN
HAMANN LAWRENCE G
BELEMA MAKONEN
DEON DANIEL H
GOOD ANDREW C
GOODRICH JASON
JAMES CLINT A
LAVOIE RICO
LOPEZ OMAR D
MARTEL ALAIN
MEANWELL NICHOLAS A
NGUYEN VAN N
ROMINE JEFFREY LEE
RUEDIGER EDWARD H
SNYDER LAWRENCE B
ST LAURENT DENIS R
YANG FUKANG
LANGLEY DAVID R
WANG GAN
HAMANN LAWRENCE G
Application Number:
JP2015105694A
Publication Date:
October 01, 2015
Filing Date:
May 25, 2015
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
A61K31/4178; A61K31/13; A61K31/4745; A61K31/7056; A61K31/7105; A61K38/21; A61K38/22; A61K45/00; A61K48/00; A61P1/16; A61P31/14; A61P43/00
Domestic Patent References:
| JP5235882B2 | 2013-07-10 | |||
| JP2001505585A | 2001-04-24 | |||
| JP2005524628A | 2005-08-18 | |||
| JP5769749B2 | 2015-08-26 |
Foreign References:
| WO2006133326A1 | 2006-12-14 | |||
| WO2007031791A1 | 2007-03-22 |
Attorney, Agent or Firm:
Samejima Mutsumi
Kyousei Tamura
Nagatoshi Shinagawa
Kure Hidenori
Kyousei Tamura
Nagatoshi Shinagawa
Kure Hidenori
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