HIV INHIBITING PYRIMIDINE DERIVATIVE - JANSSEN PHARMACEUTICA NV

Title:

HIV INHIBITING PYRIMIDINE DERIVATIVE

Document Type and Number:

Japanese Patent JP2010077140

Kind Code:

A

Abstract:

To provide a new compound having improved ability of inhibiting replication of human immunodeficiency virus (HIV), and especially having improved ability of inhibiting replication of mutant strains thereof, that is, strains resistant to one or a plurality of known medicines (medicine resistant or a plurality of medicines resistant HIV strains).

There are provided compounds represented by formula (1) [wherein, -a and -b represent C or a hetero atom; n is 0-5; m is 1-4; R represents H, alkyl, hetero atom-substituted alkyl, phenyl, heterocycle or the like], the N-oxides, pharmaceutically acceptable addition salts, quaternary amine and HIV replication inhibitor of stereochemically isomeric forms, thereof; use thereof as a medicine, method of production thereof and medicinal compositions containing them.

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Inventors:

GUILLEMONT JEROME EMILE GEORGE
PALANDJIAN PATRICE
DE JONGE MARC RENE
KOYMANS LUCIEN MARIA HENRICUS
VINKERS HENDRIK MAARTEN
DAEYAERT FREDERIK FRANS DESIRE
JEAN HEERESU
VAN AKEN KOEN JEANNE ALFONS
LEWI PAULUS JOANNES
PAUL ADRIAN JEAN JANSSEN

Application Number:

JP2009259107A

Publication Date:

April 08, 2010

Filing Date:

November 12, 2009

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NV

International Classes:

C07D239/48; A61K31/505; A61K31/506; A61K31/5355; A61K31/5377; A61K31/541; A61K31/551; A61K45/00; A61P31/18; C07C211/00; C07C255/42; C07C257/12; C07D233/96; C07D239/47; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D407/12; C07D409/12; C07D413/12; C07D417/12; C07D239/46; A61K; C07C; C07D

Domestic Patent References:

JPS5879920A

1983-05-13

Foreign References:

US3953398A

1976-04-27

Attorney, Agent or Firm:

Patent business corporation Odashima patent office

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