Title:
HIV PROTEASE INHIBITOR USEFUL FOR TREATING AIDS
Document Type and Number:
Japanese Patent JPH05345775
Kind Code:
A
Abstract:
PURPOSE: To provide an inhibitor useful for prevention and, treatment of HIV infection and for treatment of AIDS.
CONSTITUTION: This compound is represented by formula A-G-B-B-J, e.g. N-[2-(R)-hydroxyl-1(S)-indanyl]-5-(S)-(1,1-dimethylethoxycarbonylamino)-4(S)- hydroxy-6-phenyl-2-(R)-((4-(2-(4-morphorinyl)ethoxy)phenyl)methyl)hexanamide. The compound of the formula is prepared starting from the compound of formula III. In the formula, A is H, R1-CO-(R1 is H, 1-6C alkyl or the like) or the like; G is formula I [Z is O, S, or the like; R9, R10 are each -(CH2)n-R11 [(n) is 0 to 5; R11 is H, 1-4C alkyl or the like] or the like; Q is formula II or the like] or the like; B is absent or formula III [R21 is -CH(CH3)2 or the like] or the like; J is YR17 (R17 is H, 1-6C alkyl or the like; Y is O, NH) or the like.
Inventors:
THOMPSON WAYNE J (US)
VACCA JOSEPH P (US)
HUFF JOEL R (US)
LYLE TERRY A (US)
YOUNG STEVEN D (US)
HUNGATE RANDALL W (US)
BRITCHER SUSAN F (US)
GHOSH ARUN K (US)
Application Number:
JP41933790A
Publication Date:
December 27, 1993
Filing Date:
December 18, 1990
Assignee:
MERCK & CO INC (US)
International Classes:
A61K31/16; A61K31/17; A61K31/18; A61K31/19; A61K31/215; A61K31/265; A61K31/335; A61K31/34; A61K31/341; A61K31/35; A61K31/351; A61K31/357; A61K31/535; A61K31/5375; A61K31/66; A61K31/665; A61K31/675; A61P31/12; A61P31/18; C07C237/22; C07C271/22; C07D213/04; C07D213/72; C07D215/48; C07D233/60; A61K31/13; C07D235/14; C07D249/08; C07D265/30; C07D295/04; C07D295/08; C07D295/092; C07D295/155; C07D295/215; C07D307/02; C07D307/12; C07D307/16; C07D307/20; C07D307/24; C07D307/33; C07D307/42; C07D307/54; C07D309/02; C07D309/04; C07D309/06; C07D309/08; C07D309/12; C07D311/04; C07D311/68; C07D317/14; C07D317/18; C07D317/24; C07D319/20; C07D335/06; C07D413/12; C07D453/00; C07D493/04; C07F9/38; C07F9/6533; C07H13/04; C07D; (IPC1-7): C07D295/08; A61K31/13; A61K31/16; A61K31/17; A61K31/18; A61K31/19; A61K31/215; A61K31/265; A61K31/335; A61K31/34; A61K31/35; A61K31/535; A61K31/66; A61K31/665; A61K31/675; C07D213/72; C07D215/48; C07D249/08; C07D307/12; C07D309/06; C07D317/18; C07D319/20; C07D413/12; C07D453/00; C07D493/04; C07F9/38
Attorney, Agent or Firm:
Masao Okabe (6 others)
