METHODS FOR COMBINED CONDITIONING AND CHEMOSELECTION IN A SINGLE CYCLE

Title:

METHODS FOR COMBINED CONDITIONING AND CHEMOSELECTION IN A SINGLE CYCLE

Document Type and Number:

Japanese Patent JP2017008090

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide effective radiation-free methods for transplanting hematopoietic stem cells (HSC) to reconstruct bone marrow cells while avoiding radiation-induced toxicity.SOLUTION: Provided is an agent for use in an HSC transplantation method, comprising a purine base analog selected from 6-thioguanine, 6-mercaptopurine and azathiopurine, where the method comprises a single cycle of the steps of: (a) administering to a mammalian subject one or two doses of 2 to 10 mg/kg body weight of a purine base analog as a pre-conditioning step; (b) engrafting into the subject hypoxanthine-guanine phosphoribosyltransferase (HPRT)-deficient donor HSCs within 48 to 72 hours of the pre-conditioning step; and (c) administering to the subject about 1 to 5 mg/kg of the purine base analog every two to four days for two to eight weeks following the engrafting step, where the administration is started immediately after the engrafting step (b) and the method is performed in the absence of pre-conditioning via radiation.SELECTED DRAWING: Figure 5

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Inventors:

KASAHARA NORIYUKI
ROBERT H SCHIESTL
KATRIN HACKE
AKOS SZAKMARY
GAY M CROOKS

Application Number:

JP2016164295A

Publication Date:

January 12, 2017

Filing Date:

August 25, 2016

Export Citation:

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Assignee:

UNIV CALIFORNIA

International Classes:

A61K35/28; A61K31/52; A61K35/12; A61P7/00; A61P35/02

Domestic Patent References:

JP5997257B2	2016-09-28
JP5997257B2	2016-09-28

Foreign References:

US20030032003A1	2003-02-13
US20030032003A1	2003-02-13

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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