Title:
URLC8のtRNA-ジヒドロウリジンシンターゼ活性によって非小細胞肺癌を診断する方法
Document Type and Number:
Japanese Patent JP4908402
Kind Code:
B2
Abstract:
The present invention features a method for determining t-RNA dihydrouridine-synthase activity of a polypeptide and screening for modulators of t-RNA dihydrouridine-synthase activity. The present invention further provides methods or pharmaceutical compositions for preventing and/or treating non-small cell lung cancer (NSCLC) using such modulators. Furthermore, the present invention provides methods for diagnosing non-small cell lung cancer (NSCLC) using the t-RNA dihydrouridine-synthase activity of IMS-E21 (URLC8) protein as an index. The present invention further provides methods for predicting and prognosing lung squamous-cell carcinoma (SCC).
Inventors:
Yusuke Nakamura
Daigo Yataro
Shuichi Nakatsuru
Daigo Yataro
Shuichi Nakatsuru
Application Number:
JP2007509810A
Publication Date:
April 04, 2012
Filing Date:
September 21, 2005
Export Citation:
Assignee:
OncoTherapy Science Co., Ltd.
International Classes:
C12Q1/68; C12N15/09; C12Q1/25; G01N33/15; G01N33/50; G01N33/53; G01N33/574
Foreign References:
| WO2004031413A1 | ||||
| WO2000078954A1 | ||||
| WO2004030615A1 |
Other References:
J Pathol., 2004.08, Vol.204, No.1, pp.101-109
Mod. Pathol., 2000, Vol.13, No.11, pp.1167-1172
Lung Cancer, 1998, Vol.22, No.3, pp.191-200
RNA, 2002, Vol.8, pp.370-381
Mod. Pathol., 2000, Vol.13, No.11, pp.1167-1172
Lung Cancer, 1998, Vol.22, No.3, pp.191-200
RNA, 2002, Vol.8, pp.370-381
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki