Title:
How to prepare a Aryl acetic acid derivative and a heteroaryl acetic acid derivative
Document Type and Number:
Japanese Patent JP6100174
Kind Code:
B2
Abstract:
The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents.
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Inventors:
Himler, Thomas
Lucas Yott, Goshen
Rudolph Hueritus
Son, Bin Rui
Lucas Yott, Goshen
Rudolph Hueritus
Son, Bin Rui
Application Number:
JP2013555836A
Publication Date:
March 22, 2017
Filing Date:
February 27, 2012
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
International Classes:
C07C67/343; C07C69/614; C07C69/616; C07C69/738; C07C69/76; C07C201/14; C07C205/56; C07C253/30; C07C255/57; C07C319/20; C07C323/62; C07D333/24
Domestic Patent References:
| JP2010516454A | ||||
| JP2002540097A | ||||
| JP2009515974A | ||||
| JP2001081065A | ||||
| JP2013517255A | ||||
| JP2004534774A |
Foreign References:
| WO2008044700A1 |
Other References:
Kondo, Yoshinori et al.,Palladium catalyzed arylation of malonate accompanying in situ dealkoxycarbonylation,Chemical Communications,2001年,pp.2704-2705
Choudary, B. M. et al.,Palladium catalyzed carbonylation of organic halides: the first example of carbonylation under solid-liquid phase transfer conditions,Applied Catalysis,1987年,vol.32 no.1-2,pp.357-359
Choudary, B. M. et al.,Palladium catalyzed carbonylation of organic halides: the first example of carbonylation under solid-liquid phase transfer conditions,Applied Catalysis,1987年,vol.32 no.1-2,pp.357-359
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Takuya Gomibuchi
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Takuya Gomibuchi
Yoshikazu Iwase
Yasufumi Shiroyama
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