Title:
ヒト血小板糖タンパクIb/IXのミモトープおよび抗-ミモトープ
Document Type and Number:
Japanese Patent JP3979448
Kind Code:
B2
Abstract:
The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.
Inventors:
Jonathan El. Miller
Vicky A. Lyle
Vicky A. Lyle
Application Number:
JP51892897A
Publication Date:
September 19, 2007
Filing Date:
November 08, 1996
Export Citation:
Assignee:
RCS Beatty, LRC Series ii
International Classes:
A61K45/00; C07K7/06; A61K38/00; A61P7/02; A61P43/00; C07K14/00; C07K14/705; C07K16/28
Other References:
British Journal of Haematology,1990,Vol.74,p.313-319
Blood,1987,Vol.69,No.2,p.570-577
Science,1990,Vol.249,p.386-390
Blood,1987,Vol.69,No.2,p.570-577
Science,1990,Vol.249,p.386-390
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo