HUMANIZED T CELL MEDIATED IMMUNE RESPONSES IN NON-HUMAN ANIMALS

Title:

HUMANIZED T CELL MEDIATED IMMUNE RESPONSES IN NON-HUMAN ANIMALS

Document Type and Number:

Japanese Patent JP2022140609

Kind Code:

A

Abstract:

To provide genetically engineered non-human animals (e.g., rodents, e.g., mice or rats).SOLUTION: Non-human animals genetically engineered may express a humanized T cell co-receptor (e.g., humanized CD4 and/or CD8 (e.g., CD8α and/or CD8β)), a human or humanized T cell receptor (TCR) comprising a variable domain encoded by at least one human TCR variable region gene segment, and/or a human or humanized major histocompatibility complex that binds the humanized T cell co-receptor (e.g., human or humanized MHC II (e.g., MHC II α and/or MHC II β chains) and/or MHC I (e.g., MHC I α) respectively, and optionally human or humanized β2 microglobulin).SELECTED DRAWING: None

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Inventors:

Lynn McDonald
Andrew Jay. Murphy
Cagan regular
Christos Karatuos

Application Number:

JP2022122754A

Publication Date:

September 26, 2022

Filing Date:

August 01, 2022

Export Citation:

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Assignee:

REGENERON PHARMACEUTICALS, INC.

International Classes:

C12N15/12; A01K67/027; C07K14/705; C07K14/725; C07K14/73; C07K14/74; C07K19/00; C12N5/0735; C12N5/078; C12N5/10; C12N5/16; C12N15/62; C12N15/63; C12N15/90; C40B40/08; C40B40/10

Domestic Patent References:

JP2014532413A	2014-12-08
JP2005505236A	2005-02-24

Foreign References:

WO2014130671A1	2014-08-28
WO2014164640A1	2014-10-09
WO2014130667A1	2014-08-28

Attorney, Agent or Firm:

Shusaku Yamamoto
Morishita Natsuki

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