Title:
HYDROXY-TETRAHYDROPYRIDINE LACTONES
Document Type and Number:
Japanese Patent JPS60132988
Kind Code:
A
Abstract:
Hydroxytetrahydropyridinelactones of the formula in which R represents a phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, quinolyl, isoquinolyl, indolyl, benzimidazolyl, quinazolyl, quinoxalyl, thionaphthenyl, isothionaphthenyl, chromonyl, thiochromonyl, chromenyl, thiochromenyl, benzoxadiazolyl or benzthiadiazolyl radical, and the stated radicals may carry 1 to 3 identical or different substituents from the group comprising C1-C20-alkyl, C2-C20-alkenyl, C2-C20-alkinyl, C1-C20-alkoxy, fluorine, chlorine, bromine, iodine, trifluoromethyl, monofluoro-C1-C10-alkoxy, polyfluoro-C1-C10-alkoxy, hydroxyl, amino, mono-C1-C10-alkylamino, di-C1-C10-alkylamino, nitro, cyano, azido, carboxyl, carb-C1-C10-alkoxy, carboxamido, sulphonamido, SOm-alkyl (m=0 to 2, 1 to 20 C atoms), phenyl, benzyl, benzyloxy or benzylthio, it being possible for the 4 last-mentioned substituents to carry 1 to 3 radicals from the group comprising C1-C5-alkyl, C1-C5-alkoxy, C1-C5-alkylthio, fluorine, chlorine, bromine, iodine, cyano, nitro, azido, hydroxyl, trifluoromethyl, amino, C1-C6-alkylamino or di-C1-C6-alkylamino, R1 represents a straight-chain, branched or cyclic saturated or unsaturated hydrocarbon radical which has 1-20 C atoms, may be interrupted in the chain by 1 or 2 oxygen or sulphur atoms and may be optionally substituted by one or more fluorine atoms, NO2, C3-C12-trialkyl-silyl, hydroxyl, chlorine, bromine, iodine or cyano, R2 represents hydrogen, -NH2, -CHO, cyano, -CH2OH or a straight-chain or branched saturated or unsaturated hydrocarbon radical having 1 to 8 C atoms, R3 represents hydrogen or a straight-chain or branched C1-C10-alkyl radical which may be interrupted in the alkyl chain by one or two oxygen atoms and may be optionally substituted by fluorine, chlorine, bromine, iodine, -CN, -NH2, -OH or morpholino, which can be used as cardiotonics for improving the contractility of the heart. Moveover, they increase the flow of Ca++ into the cells and can therefore be employed as antihypotonics, for lowering the blood sugar level, for reducing the swelling of mucous membranes and for influencing the salt balance and/or fluid balance.
Inventors:
KURAUSU GERURITSUTSUAA
URURITSUHI BARUTOKE
JIIKUFURIITO GORUTOMAN
MATEIASU SHIYURAMU
GIYUNTAA TOOMASU
RAINAA GUROOSU
URURITSUHI BARUTOKE
JIIKUFURIITO GORUTOMAN
MATEIASU SHIYURAMU
GIYUNTAA TOOMASU
RAINAA GUROOSU
Application Number:
JP25203784A
Publication Date:
July 16, 1985
Filing Date:
November 30, 1984
Export Citation:
Assignee:
BAYER AG
International Classes:
A61K31/435; A61K31/47; A61K31/505; A61P3/00; A61P3/08; A61P9/04; C07D211/90; C07D491/04; C07D491/048; C07F7/10; (IPC1-7): A61K31/435; A61K31/47; A61K31/505; C07D491/048; C07F7/10
Attorney, Agent or Firm:
Heiyoshi Odashima