Title:
IL-1結合タンパク質
Document Type and Number:
Japanese Patent JP2012516153
Kind Code:
A
Abstract:
The present invention encompasses IL-1alpha binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Antibodies of the invention have high affinity for IL-1alpha and neutralize IL-1alpha activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting IL-1alpha and for inhibiting IL-1alpha activity, e.g., in a human subject suffering from a disorder in which IL-1alpha activity is detrimental.
Inventors:
Chie, Ji Young-Min
Wu
Wu
Application Number:
JP2011547978A
Publication Date:
July 19, 2012
Filing Date:
January 29, 2010
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C12N15/09; A61K31/704; A61K38/00; A61K39/395; A61K45/00; A61K47/26; A61K47/32; A61K47/34; A61K47/38; A61K47/40; A61K47/42; A61K49/00; A61K51/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P3/14; A61P7/00; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P13/08; A61P13/12; A61P15/08; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/14; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/06; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P25/32; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P33/02; A61P33/06; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; C07K16/24; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; G01N33/68
Domestic Patent References:
| JP2009504191A | 2009-02-05 | |||
| JP2004502428A | 2004-01-29 | |||
| JPS63258595A | 1988-10-26 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office