Title:
IL-17異種ポリペプチドとその治療上の用途
Document Type and Number:
Japanese Patent JP5451496
Kind Code:
B2
Abstract:
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterolgous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Inventors:
Arno, david
Gurney, Austin
Lotus, philip
Lee, james
Wu, Yang
Gurney, Austin
Lotus, philip
Lee, james
Wu, Yang
Application Number:
JP2010088577A
Publication Date:
March 26, 2014
Filing Date:
April 07, 2010
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C12N15/09; C07K14/54; C07K16/24; C12N15/13; C12N15/24; G01N33/68; A61K38/00; A61K39/395; A61K45/00; A61P1/04; A61P1/16; A61P3/10; A61P5/00; A61P7/00; A61P7/06; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P21/00; A61P25/00; A61P31/04; A61P31/10; A61P31/12; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P33/00; A61P37/00; A61P37/06; A61P37/08; C07K14/715; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP11510045A |
Foreign References:
| WO2001046420A1 |
Other References:
EMBO J,2001年,vol.20, no.19,p.5332-5341
J Exp Med,1996年,vol.183, no.6,p.2593-2603
J.Mol.Biol.,Vol.321(2002)p.851-862
J Exp Med,1996年,vol.183, no.6,p.2593-2603
J.Mol.Biol.,Vol.321(2002)p.851-862
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori