Title:
【発明の名称】抗ウイルス剤としての2’,5’―ヌクレオチド類似体
Document Type and Number:
Japanese Patent JPH06500568
Kind Code:
A
Abstract:
There is provided the use of a nucleotide analog of formula (I) wherein R1 represents (i) a hydrogen atom, (ii) a 2' or 3'-P-thionucleotidyl residue conjugated at its 5' position with an acyl group, (iii) a phosphoryl group, a P-thiophosphoryl group, a PO2R<2>H group optionally esterified with a linear or branched, cyclic or acyclic aliphatic hydroxy alkyl group having from 1 to 6 carbon atoms or with a lipophilic moiety or (iv) an acyl group; R<2> represents a C1-C6 alkyl group or hydrogen atom, and the pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use as an antiviral, antitumour, immunomodulatory, interferon-enhancing or interferon-inducing agent. Some compounds of formula (I) are new. A process for their preparation and pharmaceutical compositions comprising them are also provided.
Inventors:
Battue Staini, Carlo
Blasca, Maria Gabriella
Giordani, Antonio
Fustinoni, Sylvia
Hermoli, Antonella
Blasca, Maria Gabriella
Giordani, Antonio
Fustinoni, Sylvia
Hermoli, Antonella
Application Number:
JP50919092A
Publication Date:
January 20, 1994
Filing Date:
May 14, 1992
Export Citation:
Assignee:
Faria Talia Carlo Erba Etsuse Elle Elle
International Classes:
A61K31/70; A61P31/12; C07H21/00; C07H21/02; C07H21/04; (IPC1-7): C07H21/02; A61K31/70
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)