Title:
【発明の名称】5-HT3受容体拮抗剤としての2,6‐メタノ‐2H‐キノリジン誘導体
Document Type and Number:
Japanese Patent JPH07504192
Kind Code:
A
Abstract:
This invention relates to 5-chloro-2, 3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acid-octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester (I), a novel 5-HT3-receptor antagonist, its method of preparation, and to its end-use application in the treatment of radio- and chemo-therapeutically-induced nausea and vomiting, in the treatment of pain associated with migraine, in the treatment of cognitive disorders, in treating hallucinatory endogenous psychoses of the type manifested in patients suffering from schizophrenia and mania, for irritable bowel syndrome, and to combat drug abuse.
Inventors:
Jits, Maurice W.
Application Number:
JP51486893A
Publication Date:
May 11, 1995
Filing Date:
February 03, 1993
Export Citation:
Assignee:
Merrell Dow Farmas-Tikals Incorporated
International Classes:
A61K31/435; A61P1/08; A61P25/04; A61P25/18; A61P25/24; A61P25/26; C07D471/18; (IPC1-7): C07D471/18
Attorney, Agent or Firm:
Katsuro Sasai