Title:
【発明の名称】システインプロテアーゼ阻害薬としてのアシル化アミノアセトニトリル類
Document Type and Number:
Japanese Patent JP2002537285
Kind Code:
A
Abstract:
A compound of formula (I): wherein R<1>, R<2>, R<3> and Ar are defined; a composition comprising a compound of formula (I) and a carrier or diluent; a compound of formula (I) for use as a medicament; the use of a compound of formula (I) in the manufacture of a medicament for use in the inhibition of a cysteine protease in a warm blooded animal; the use of a compound of formula (I) in the manufacture of a medicament for use in the treatment of chronic obstructive pulmonary disease in a warm blooded animal; and a method of treating a Cathepsin L or Cathepsin S mediated disease state in mammals which comprises administering to a mammal in need of such treatment an effective amount of a compound of formula (I).
Inventors:
Tucker, Howard
Large, Michael Stuart
Oldfield, John
Johnston, Craig
Edwards, Philip Nail
Large, Michael Stuart
Oldfield, John
Johnston, Craig
Edwards, Philip Nail
Application Number:
JP2000599733A
Publication Date:
November 05, 2002
Filing Date:
February 16, 2000
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D249/18; A61K31/275; A61K31/33; A61K31/341; A61K31/381; A61K31/4192; A61K31/4402; A61K31/5375; A61P9/10; A61P11/00; A61P19/00; A61P19/08; A61P21/00; A61P29/00; A61P43/00; C07C255/25; C07C255/29; C07C321/14; C07C323/60; C07D213/30; C07D231/12; C07D295/08; C07D307/54; C07D333/24; (IPC1-7): C07C255/29; A61K31/275; A61K31/341; A61K31/381; A61K31/4192; A61K31/4402; A61K31/5375; A61P9/10; A61P11/00; A61P19/08; A61P21/00; A61P29/00; A61P43/00; C07C321/14; C07D213/30; C07D249/18; C07D295/08; C07D307/54; C07D333/24
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)