Title:
【発明の名称】IL-1βおよびTNF-αの抑制剤としてのアミノベンゾフェノン
Document Type and Number:
Japanese Patent JP2003505363
Kind Code:
A
Abstract:
The present invention relates to compounds of the formulawherein R1 independently represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, phenyl and nitro, provided that when R1 represents one substituent, it is in the ortho position, and when R1 represents more than one substituent, at least one R1 substituent is in the ortho position; R2 is one substituent in the ortho position, said substituent being selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, phenyl and nitro; R3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, phenyl, cyano, carboxy, or carbamoyl; R4 represents hydrogen, (C1-C3)alkyl, or allyl. The compounds are valuable in the human and veterinary therapy.
Inventors:
Eric Ritter Otsen
Application Number:
JP2001511412A
Publication Date:
February 12, 2003
Filing Date:
July 11, 2000
Export Citation:
Assignee:
LEO Pharma A/S
International Classes:
A61K31/17; A61K31/192; A61K31/198; A61K31/405; A61K31/4402; A61P1/00; A61P7/06; A61P9/10; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P37/08; C07C275/28; A61K45/00; C07C275/40; C07C275/42; C07C311/60; (IPC1-7): C07C275/40; A61K31/17; A61K31/192; A61K31/198; A61K31/405; A61K31/4402; A61K45/00; A61P1/00; A61P9/10; A61P11/06; A61P17/00; A61P17/02; A61P19/02; A61P19/06; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P37/08; C07C275/42; C07C311/60
Domestic Patent References:
| JP2001511771A | 2001-08-14 |
Foreign References:
| WO1998032730A1 | 1998-07-30 |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)