Title:
【発明の名称】結腸用薬物送達システム
Document Type and Number:
Japanese Patent JPH05508631
Kind Code:
A
Abstract:
A colonic delivery system for delivering a drug to the colon is provided. The system comprises a drug in combination with a matrix, wherein the matrix comprises a saccharide-containing polymer. According to the invention, the matrix is resistant to chemical and enzymatic degradation in the stomach and small intestine. The matrix is degraded in the colon by bacterial enzymatic action, and the drug is released. The system is useful for targeting drugs to the colon in order to treat colonic disease. The system is also useful for enteric administration of drugs such as proteins and peptides which are otherwise degraded in the stomach and small intestine.
Inventors:
Sintov, Amnon
Rubinstein, Abraham
Rubinstein, Abraham
Application Number:
JP51059591A
Publication Date:
December 02, 1993
Filing Date:
May 02, 1991
Export Citation:
Assignee:
Issam Research Development Company of the Hebrew University of Jerusalem
Perio Products Limited
Perio Products Limited
International Classes:
A61K9/14; A61K9/20; A61K9/00; A61K9/50; A61K47/36; C08B37/00; (IPC1-7): A61K9/00; A61K47/36
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)