Title:
【発明の名称】マトリックスメタロプロテアーゼ阻害因子
Document Type and Number:
Japanese Patent JPH09505038
Kind Code:
A
Abstract:
This invention is directed to compounds of formula (I): wherein R<1> is mercapto, acetylthio, carboxy, hydroxycarbamoyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, benzyloxycarbamoyl or (i) (where R<6> is optionally substituted aryl, wherein the aryl group is quinol-2-yl, naphth-1-yl, naphth-2-yl, pyridyl or phenyl); R<2> is alkyl, aralkyl or cycloalkylalkyl; R<3> is cycloalkyl, alkyl (optionally substituted by cycloalkyl, hydroxy, mercapto, alkylthio, aralkoxy, carboxy, amino, alkylamino, guanidino, carbamoyl, pyridyl or indolyl), or aralkyl (optionally substituted by hydroxy, carboxy, alkyl or alkoxy); R<4> is nitro, amino, cyano, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkylsulfonyl, haloalkyl, alkoxycarbonylalkyl, tetrazolyl, carbamoyl (optionally substituted by alkyl or dialkylaminoalkyl), or aminosulfonyl (optionally substituted by alkyl); and R<5> is hydrogen, halo or hydroxy; as single stereoisomers or as mixtures thereof; or the pharmaceutically acceptable salts thereof. These compounds are useful in inhibiting matrix metalloprotease activity in mammals.
Inventors:
CASTELHANO ARLINDO L (US)
YUAN ZHENGYU (US)
HORNE STEPHEN (CA)
LIAK TENG J (CA)
YUAN ZHENGYU (US)
HORNE STEPHEN (CA)
LIAK TENG J (CA)
Application Number:
JP51326795A
Publication Date:
May 20, 1997
Filing Date:
November 03, 1994
Export Citation:
Assignee:
SYNTEX INC (US)
International Classes:
A61K31/195; A61K31/215; A61K31/235; A61K31/403; A61K31/404; A61K31/405; A61K31/44; A61K31/4406; A61K31/4418; A61K31/662; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07C51/60; C07C53/42; C07C57/72; C07C67/313; C07C67/317; C07C69/353; C07C69/533; C07C233/47; C07C237/22; C07C237/42; C07C255/57; C07D213/82; C07C255/60; C07C259/06; C07C271/22; C07C279/14; C07C311/46; C07C317/38; C07C317/40; C07C323/52; C07C323/59; C07C323/60; C07C323/63; C07C327/12; C07C327/22; C07C327/32; C07D209/20; C07D213/75; C07D263/26; C07D295/13; C07F9/30; C07F9/32; C07F9/34; C07F9/36; C07F9/48; C07F9/58; C07F9/60; C07F9/62; C07F9/6558; (IPC1-7): C07C237/22; C07F9/62; C07F9/58; C07F9/36; C07F9/34; C07F9/30; C07D213/82; C07D209/20; C07C327/22; C07C323/52; C07C317/38; C07C311/46; C07C271/22; C07C69/533; C07C69/353; C07C67/317; C07C67/313; C07C57/72; C07C53/42; C07C51/60; A61K31/44; A61K31/405; A61K31/235; A61K31/215
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)