Title:
【発明の名称】プレニル蛋白トランスフェラーゼ阻害薬
Document Type and Number:
Japanese Patent JP2001518508
Kind Code:
A
Abstract:
The present invention is directed to compounds which inhibit a prenyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting a prenyl-protein transferase and the prenylation of the oncogene protein Ras.
Inventors:
De Solms, S. Jean
Hatsuchinson, Jiyoung H
Anthony Davrilleu
Graham, Samuel El
Sitka Lawn, Terence M
Hatsuchinson, Jiyoung H
Anthony Davrilleu
Graham, Samuel El
Sitka Lawn, Terence M
Application Number:
JP2000514648A
Publication Date:
October 16, 2001
Filing Date:
October 07, 1998
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
C07D249/08; A61K31/416; A61K31/4164; A61K31/4184; A61K31/4196; A61K31/4427; A61K31/4439; A61K31/496; A61K31/5355; A61K31/5377; A61P9/10; A61P13/12; A61P31/10; A61P31/12; A61P35/00; C07D233/54; C07D233/60; C07D233/61; C07D233/66; C07D233/90; C07D235/06; C07D401/12; C07D401/14; C07D403/12; C07D521/00; (IPC1-7): C07D233/60; A61K31/416; A61K31/4164; A61K31/4184; A61K31/4196; A61K31/4439; A61K31/496; A61K31/5377; A61P9/10; A61P13/12; A61P31/10; A61P31/12; A61P35/00; C07D235/06; C07D249/08; C07D401/12; C07D401/14; C07D403/12
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)