Title:
【発明の名称】高分子量キニノゲン及びそのペプチド類似体による血管形成の抑制
Document Type and Number:
Japanese Patent JP2002529474
Kind Code:
A
Abstract:
Two-chain high molecular weight kininogen, and peptide analogs thereof having homology to sites within kininogen domain 5, are potent inhibitors of angiogenesis. The peptides have the formula X1-His-Lys-X-Lys-X2 wherein X is any amino acid, X1 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids, and X2 is from zero to twelve amino acids, more preferably from zero to six amino acids, most preferably from zero to three amino acids. X is preferably an amino acid having a nonpolar side chain, or a polar side chain which is uncharged at pH 6.0 to 7.0. X is most preferably Asn, Phe or His. Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.
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Inventors:
Keith Earl. McRae
Application Number:
JP2000581043A
Publication Date:
September 10, 2002
Filing Date:
November 05, 1999
Export Citation:
Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
International Classes:
C12N5/07; A61K38/00; A61K38/48; A61P9/00; A61P27/02; A61P35/00; A61P43/00; C07K7/08; C07K14/00; C07K14/81; C12N5/071; (IPC1-7): A61K38/00; A61K38/48; A61P9/00; A61P27/02; A61P35/00; A61P43/00; C07K7/08; C07K14/00; C07K14/81; C12N5/06
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)