Title:
【発明の名称】チューブリン結合化合物(COBRA)
Document Type and Number:
Japanese Patent JP2002534355
Kind Code:
A
Abstract:
Novel tubulin binding compounds having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel tubulin binding pocket, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.
Inventors:
Ukkun, Fatty, M.
Jean, Shy-Thailand, M.
Mao, Chen
Jean, Shy-Thailand, M.
Mao, Chen
Application Number:
JP2000557244A
Publication Date:
October 15, 2002
Filing Date:
June 29, 1999
Export Citation:
Assignee:
Parker Hughes Institute
International Classes:
A61K31/341; A61P35/00; A61P43/00; C07C323/41; C07D307/12; C07D307/42; C07K14/47; C07K14/82; (IPC1-7): C07D307/12; A61K31/341; A61P35/00; A61P43/00; C07C323/41; C07D307/42; C07K14/47
Attorney, Agent or Firm:
Hiroyuki Ikeuchi (3 outside)