Title:
【発明の名称】移植片に対する免疫寛容を誘導するための、免疫毒素および樹状細胞の成熟を阻害する作用剤を含有する組成物
Document Type and Number:
Japanese Patent JP2002541195
Kind Code:
A
Abstract:
The present invention provides a method of inducing immune tolerance to a graft in a recipient, comprising administering to the recipient an immunotoxin, thereby reducing the recipient's T-cell population; and administering to the recipient an agent that inhibits dendritic cell maturation. The present invention also provides a method of screening for an agent that acts synergistically with an immunotoxin in inducing immune tolerance and a method of screening for an agent that inhibits dendritic cell maturation. The present invention also provides a method of treating a subject with an autoimmune disease, comprising administering to the subject an immunotoxin, thereby reducing the subject's T-cell population; and administering to the subject an agent that inhibits dendritic cell maturation. Also provided herein is a composition comprising an immunotoxin and an agent that inhibits dendritic cell maturation.
Inventors:
David M Neville
Judith M. Thomas
Judith M. Thomas
Application Number:
JP2000610465A
Publication Date:
December 03, 2002
Filing Date:
April 14, 2000
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
The UAB Research Foundation
The UAB Research Foundation
International Classes:
G01N33/50; A61K31/16; A61K31/567; A61K38/00; A61K39/395; A61K45/00; A61K45/06; A61K47/48; A61K49/00; A61P37/02; A61P37/06; A61P43/00; G01N33/15; (IPC1-7): A61K45/06; A61K31/16; A61K31/567; A61K38/00; A61K45/00; A61P37/06; A61P43/00; G01N33/15; G01N33/50
Domestic Patent References:
| JPH11503309A | 1999-03-26 |
Foreign References:
| WO1998039363A2 | 1998-09-11 |
Other References:
JPN5002006772, ＣＯＮＴＲＥＲＡＳ， Ｊ．Ｌ．， ｅｔ ａｌ．, "ＰＥＲＩＴＲＡＮＳＰＬＡＮＴ ＴＯＬＥＲＡＮＣＥ ＩＮＤＵＣＴＩＯＮ ＷＩＴＨ ＡＮＴＩ−ＣＤ３−ＩＭＭＵＮＯＴＯＸＩＮ", ＴＲＡＮＳＰＬＡＮＴＡＴＩＯＮ, 19980515, Ｖｏｌ．６５， Ｎｏ．９, ｐ．１１５９−１１６９
JPN6010029024, ＡＮＤＯＩＮＳ， Ｃ．， ｅｔ ａｌ．, "ＴＯＬＥＲＡＮＣＥ ＩＮ Ａ ＲＡＴ ＣＡＲＤＩＡＣ ＡＬＬＯＧＲＡＦＴ ＭＯＤＥＬ ＡＦＴＥＲ ＳＨＯＲＴ−ＴＥＲＭ ＴＲＥＡＴＭＥＮＴ ＷＩＴＨ ＬＦ ０８−０２９９", ＴＲＡＮＳＰＬＡＮＴＡＴＩＯＮ, 19961215, Ｖｏｌ．６２， Ｎｏ．１１, ｐ．１５４３−１５４９
JPN6010029030, ＡＮＴＯＮＹＳＡＭＹ， Ｍ．Ａ．， ｅｔ ａｌ．, "Ｅｖｉｄｅｎｃｅ ｆｏｒ ａ Ｒｏｌｅ ｏｆ ＩＬ−１７ ｉｎ Ｏｒｇａｎ Ａｌｌｏｇｒａｆｔ Ｒｅｊｅｃｔｉｏｎ： ＩＬ−１７ Ｐｒｏｍｏｔｅｓ ｔｈｅ Ｆｕｎｃｔｉｏｎａｌ Ｄｉｆｆｅｒｅｎｔｉａ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ, 19990101, Ｖｏｌ．１６２， Ｎｏ．１, ｐ．５７７−５８４
JPN6010029024, ＡＮＤＯＩＮＳ， Ｃ．， ｅｔ ａｌ．, "ＴＯＬＥＲＡＮＣＥ ＩＮ Ａ ＲＡＴ ＣＡＲＤＩＡＣ ＡＬＬＯＧＲＡＦＴ ＭＯＤＥＬ ＡＦＴＥＲ ＳＨＯＲＴ−ＴＥＲＭ ＴＲＥＡＴＭＥＮＴ ＷＩＴＨ ＬＦ ０８−０２９９", ＴＲＡＮＳＰＬＡＮＴＡＴＩＯＮ, 19961215, Ｖｏｌ．６２， Ｎｏ．１１, ｐ．１５４３−１５４９
JPN6010029030, ＡＮＴＯＮＹＳＡＭＹ， Ｍ．Ａ．， ｅｔ ａｌ．, "Ｅｖｉｄｅｎｃｅ ｆｏｒ ａ Ｒｏｌｅ ｏｆ ＩＬ−１７ ｉｎ Ｏｒｇａｎ Ａｌｌｏｇｒａｆｔ Ｒｅｊｅｃｔｉｏｎ： ＩＬ−１７ Ｐｒｏｍｏｔｅｓ ｔｈｅ Ｆｕｎｃｔｉｏｎａｌ Ｄｉｆｆｅｒｅｎｔｉａ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ, 19990101, Ｖｏｌ．１６２， Ｎｏ．１, ｐ．５７７−５８４
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)