Title:
【発明の名称】透明帯ポリペプチドによる同種免疫化に基づく避妊ワクチン
Document Type and Number:
Japanese Patent JPH08511239
Kind Code:
A
Abstract:
The present invention relates to contraceptive vaccines based on cloned zona pellucida genes and the strategy of alloimmunization with zona pellucida polypeptides. In particular, the present invention relates to a contraceptive vaccine for use in a mammalian female comprising a polypeptide which displays at least one epitope for binding of an antibody that inhibits fertilization of an oocyte by a sperm. This epitope is from a zona pellucida protein of the species in which the said vaccine is used. This invention relates, more particularly, to such vaccines wherein the zona pellucida protein is the ZP3 protein or portions thereof of the mouse or homologues of these proteins in some other mammalian species. Further, this invention comprehends vaccines comprising a synthetic peptide that displays an epitope for such an antibody that inhibits fertilization. In addition, this invention relates to cloned DNA segments encoding the human ZP3 protein.
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Inventors:
Dean, Julien
Application Number:
JP52222394A
Publication Date:
November 26, 1996
Filing Date:
March 25, 1994
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
C12N15/09; A61K39/00; A61K39/395; A61P15/18; C07K7/08; C07K14/705; C07K16/18; C07K16/28; C12N15/12; (IPC1-7): C07K7/08; A61K39/00; C07K16/18; C12N15/09
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)