Title:
【発明の名称】ホウ素を含有するホルモン類似体及びホルモン受容体を有する細胞をイメージング若しくは殺すためにこれらを使用する方法
Document Type and Number:
Japanese Patent JPH11505504
Kind Code:
A
Abstract:
Boron containing compounds are targeted to hormonally responsive cells by contacting the cells with a conjugate of a boron containing moiety conjugated to a ligand having binding specificity for an intracellular receptor of the cell. The conjugates are useful for imaging or killing hormonally responsive cells, such as hormonally responsive tumor cells. For target cell killing, the cells are contacted with a 10B containing moiety conjugated to a ligand having binding specificity for an intracellular hormone receptor of the cells. The 10B containing moiety becomes associated with the hormone receptor of the cells, which may then be irradiated with neutrons to kill the cells by boron neutron capture. For target cell imaging, the cells are contacted with a 11B containing moiety conjugated to a ligand having binding specificity for an intracellular hormone receptor of the cells, and the boron that becomes associated with the hormone receptor of the cells may then be imaged using magnetic resonance imaging techniques.
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Inventors:
Hawthorne, M. Frederick
Glaudin, Mark Tee
Glaudin, Mark Tee
Application Number:
JP50313896A
Publication Date:
May 21, 1999
Filing Date:
May 15, 1995
Export Citation:
Assignee:
Ionics Corporation
International Classes:
A61K31/69; A61K41/00; A61K47/48; A61K49/00; C07F5/02; G01N33/566; G01N33/53; (IPC1-7): C07F5/02; A61K31/69; A61K47/48; A61K49/00; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)