Title:
【発明の名称】天然産物および類縁合成化合物の心臓血管系疾患を治療する用途
Document Type and Number:
Japanese Patent JPH09502163
Kind Code:
A
Abstract:
PCT No. PCT/AU94/00297 Sec. 371 Date Nov. 30, 1995 Sec. 102(e) Date Nov. 30, 1995 PCT Filed Jun. 3, 1994 PCT Pub. No. WO94/28886 PCT Pub. Date Dec. 22, 1994Use of a compound of formula (I), wherein Ar is an aromatic ring system comprising one or more optionally substituted phenyl rings optionally linked to or fused with one or more other optionally substituted phenyl rings or one or more 5 or 6-membered, optionally substituted heterocyclic rings wherein the heteroatom is oxygen; and wherein the ring system comprises 1-4 phenyl rings and wherein Ar can be linked to another Ar via a group X wherein the Ar is independently selected; where X is optionally substituted C1-20alkylene, C2-20alkenylene or C2-20alkynylene; R is hydrogen; C1-20alkenyl, C2-20alkynyl, C2-20alkanoyl, C2-20alkynoyl, each of which can be optionally substituted; R1 is independently selected and is hydrogen; optionally substituted C1-12alkyl, C2-12alkenyl, C2-20alkynyl; -COOR'-NR'R', halogen, -OR', -COR', -CONR'R', =O, -SR', -SO3R', -SO2NR'R', -SOR', -SO2R', -NO2, -CN, glycoside, silyl; where R' is independently hydrogen; alkyl, alkenyl or alkynyl each optionally substituted; and where two groups R1 can be joined; wherein the optional substituents are one or more independently selected from C1-10alkyl, C2-10alkenyl, C2-10alkynyl; -COOR''-NR''R'', halogen, OR'', -COR'', -CONR''R'', -SR'', =O, -SO3R'', -SO2NR''R'', -SOR'', -S2'', -NO2, -CN: wherein R'' is independently hydrogen, alkyl, alkenyl, or alkynyl; n=1, 2 or 3; m=1, 2, 3 or 4; or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for inhibiting the action of Ca2+-ATPase enzymes. Certain compounds of formula (I) and 8-lavandulyl flavone pharmaceutical formulations are new. (I)
Inventors:
Rhofogaris, Basildon
Duke, Colin Charles
Li, Kian
Duke, Colin Charles
Li, Kian
Application Number:
JP50110395A
Publication Date:
March 04, 1997
Filing Date:
June 03, 1994
Export Citation:
Assignee:
The University of Sidney
International Classes:
C07D311/18; A61K31/047; A61K31/05; A61K31/055; A61K31/065; A61K31/11; A61K31/12; A61K31/215; A61K31/235; A61K31/35; A61K31/352; A61K31/365; A61K31/37; A61P9/00; A61P9/04; A61P43/00; B01J27/10; C07B61/00; C07C37/01; C07C37/14; C07C39/14; C07C39/15; C07C39/16; C07C39/19; C07C39/21; C07C39/23; C07C205/22; C07C205/26; C07D311/16; C07D311/32; (IPC1-7): C07C39/15; A61K31/05; A61K31/055; A61K31/065; A61K31/11; A61K31/12; A61K31/215; A61K31/35; A61K31/37; B01J27/10; C07C37/01; C07C37/14; C07C39/14; C07C39/16; C07C39/19; C07C39/21; C07C39/23; C07C205/22; C07C205/26; C07D311/18; C07D311/32
Attorney, Agent or Firm:
Mitsuo Adachi (2 outside)