Title:
IgG分離媒体および新規プロテインA変異体
Document Type and Number:
Japanese Patent JP4117903
Kind Code:
B2
Abstract:
A separation medium having a base matrix and matrix-bound groups which exhibit recombinant Protein A containing a cysteine. The groups are of formula:where B is a bridge which binds to the base matrix and X includes a heteroatom N or S from rProtein A-cys. In a preferred embodiment X is a thioether sulphur and/or a secondary amine (-NH-). An alternative embodiment features a variant of Protein A in which the C-terminal residue is cysteine.
Inventors:
Johansson, Ingemar
Application Number:
JP51812897A
Publication Date:
July 16, 2008
Filing Date:
November 06, 1996
Export Citation:
Assignee:
GE Healthcare Bioscience Activolag
International Classes:
C12N15/09; C07K1/22; C07K14/31; C07K16/06; C12P21/02; G01N33/543
Domestic Patent References:
| JP2011523A | ||||
| JP62111688A | ||||
| JP1502076A | ||||
| JP6065294A | ||||
| JP7070179A |
Foreign References:
| WO1992009633A1 |
Other References:
Eur. J. Biochem., 1989年, Vol.186, pp.557-561
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Takuji Yamada
Mitsutaka Iwasaki
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