Title:
う蝕の予防の免疫学的方法
Document Type and Number:
Japanese Patent JP2004506695
Kind Code:
A
Abstract:
Dental caries in man may be prevented or treated by oral ingestion of human or humanized mouse monoclonal IgG and IgM antibodies that bind to surface antigens of cariogenic organisms, such as S. mutans. The genetically immune system when they bind to cariogenic organisms, resulting in their destruction. In a preferred embodiment, monoclonal antibodies to cariogenic organisms are produced by edible plants, including fruits and vegetables, transformed by DNA sequences that code on expression for the desired antibodies. The antibodies are applied by eating the plants.
Inventors:
Cee, Wenuan
Anderson, Maxwell, H.
Anderson, Maxwell, H.
Application Number:
JP2002520852A
Publication Date:
March 04, 2004
Filing Date:
August 24, 2000
Export Citation:
Assignee:
Washington Dental Service
Regents of the University of California
Regents of the University of California
International Classes:
A01H5/00; A01K67/027; A61K8/64; A61K8/97; A61K39/395; A61P1/02; A61P31/04; A61Q11/00; C07K16/12; C12N15/09; C12P21/08; (IPC1-7): A61K39/395; A61P1/02
Domestic Patent References:
| JPH05502587A | 1993-05-13 | |||
| JPH11504901A | 1999-05-11 |
Foreign References:
| US5352446A | 1994-10-04 | |||
| WO2000011037A1 | 2000-03-02 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Satoshi Fujita
Natsuo Tanaka