Title:
免疫活性化組成物
Document Type and Number:
Japanese Patent JP2008539252
Kind Code:
A
Abstract:
The present invention provides immunostimulatory compositions. Generally, the immunostimulatory compositions include at least partially purified conjugates that include at least one IRM moiety covalently coupled to an antigenic peptide. In some embodiments, the immunostimulatory composition includes monomeric conjugates. In other embodiments, the immunostimulatory composition includes an aggregate of a conjugate and at least one other antigenic peptide (e.g., another conjugate and/or unconjugated peptide). The present invention also provides methods of using such immunostimulatory compositions. In some embodiments, the methods include inducing an immune response by contacting the immunostimulatory composition with an immune cell. In other embodiments, the method includes treating a condition by administering an immunostimulatory composition to a subject in an amount effective to ameliorate at least one symptom or clinical sign of the condition.
Inventors:
Grease Glover, George W.
Keeper, William Sea.
Mendoza, James Dee.
Gram, Christopher Dee.
Keeper, William Sea.
Mendoza, James Dee.
Gram, Christopher Dee.
Application Number:
JP2008509071A
Publication Date:
November 13, 2008
Filing Date:
April 25, 2006
Export Citation:
Assignee:
3M INNOVATIVE PROPERTIES COMPANY
International Classes:
A61K39/00; A61K39/21; A61P31/04; A61P31/12; A61P35/00; C07D471/04
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Rieko Koshisakabe
Takashi Ishida
Fukumoto product
Tetsuji Koga
Rieko Koshisakabe